Computerized working memory training for hypertensive individuals with executive function impairment: a randomized clinical trial

Background Hypertension is associated with working memory (WM) impairment. However, the benefits of Cogmed WM training for hypertensive population are unknown. Therefore, we aimed to evaluate Cogmed’s effects on performance individuals executive function (EF) Methods We included 40 patients (aged 40–70 years, 68% female) EF They were randomized in a 1:1 ratio receive 10 weeks adaptive or non-adaptive control based online games. The primary outcome was performance. secondary outcomes verbal memory, visuospatial ability, function, global cognition, and neuronal activity measured using functional magnetic resonance imaging (fMRI) under two task conditions: low (memorization 4 spatial locations) high 6 locations). An intention-to-treat (ITT) per-protocol (PP) analysis performed. Results did not show significant effect any other cognitive post-training. WM-low load WM-high conditions fMRI, respectively, group had an activation decrease right superior parietal lobe (ITT PP analyses) left inferior frontal (PP analysis) comparison group. Conclusion showed no decreases observed frontoparietal areas related network, suggesting more efficient after training.